Repression of Polyol Pathway Activity by Hemidesmus indicus var. pubescens R.Br. Linn Root Extract, an Aldose Reductase Inhibitor: An In Silico and Ex Vivo Study
نویسندگان
چکیده
منابع مشابه
Protective effects of Hemidesmus indicus var. pubescens root extract on paracetamol induced hepatic damage Hemidesmus indicus var. pubescens kök ekstresinin parasetamolün oluşturduğu hepatik hasar üzerine koruyucu etkileri
AIM: This study was conducted to study the hepatoprotective property of Hemidesmus indicus (L.) R.Br. roots. METHODS: Hepatoprotective properties of the methanol extract of the roots of H. indicus var. pubescens were evaluated on paracetamol induced hepatotoxicity. Hepatotoxicity was induced in albino Wistar rats by the administration of paracetamol (1g/kg), p.o. for 7 days. Methanol extract of...
متن کاملEvaluation of Root Canal Morphology and Root Apex Anatomy of Mandibular Premolars in an Iranian Population: an ex-vivo study
Objectives Adequate knowledge about canal anatomy is necessary for clinicians to prevent any damage to the periodontium. The aim of this study was to evaluate the canal and apical complexities of the mandibular first and second premolars in an Iranian population. Methods One-hundred mandibular first (n=50) and second (n=50) premolars were collected. After access cavity preparation, 2% methylen...
متن کاملACUTE AND SUB – ACUTE TOXICITY STUDIES OF Hemidesmus indicus var. pubescens R.Br.
Toxicity studies of crude aqueous ethanolic extract of the roots of Hemidesmus indicus var. pubescens R. Br. Was carried out in two growth phases. The drug was administered orally and intra-peritonealy. It was found to possess nonspecific changes in liver. The results are discussed in detail.
متن کاملdevelopment and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولEffective fraction of Teucrium polium suppressed polyol pathway through inhibiting the aldose reductase enzyme: strategy to reduce retinopathy
Background: Several metabolic pathways are involved in the complications of diabetes like polyol pathway. Aldose reductase (AR) is a key enzyme in the polyol pathway, which catalyzes the conversion of glucose to sorbitol. AR inhibitors are appropriate to prevent and treat the diabetes complications. Objective: This study was designed to investigate the effect of different fractions of Teucrium ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Natural Products and Bioprospecting
سال: 2020
ISSN: 2192-2195,2192-2209
DOI: 10.1007/s13659-020-00290-w